ZNF384 Antibody (PACO31680)
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주문- SKU:
- PACO31680
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ZNF384 Antibody (PACO31680) |
Antibody SKU: | PACO31680 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Zinc finger protein 384 protein (1-245AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: ZNF384 antibody at 2µg/ml Lane 1: EC109 whole cell lysate Lane 2: 293T whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/15000 dilution Predicted band size: 64, 57, 51 kDa Observed band size: 64, 51, 30 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human melanoma using PACO31680 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human glioma using PACO31680 at dilution of 1:100. |
Background: | Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity). |
Synonyms: | Zinc finger protein 384 (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (Trinucleotide repeat-containing gene 1 protein), ZNF384, CAGH1 CIZ NMP4 TNRC1 |
UniProt Protein Function: | ZNF384: Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding Chromosomal Location of Human Ortholog: 12p12 Cellular Component: focal adhesion; nucleus Molecular Function:metal ion binding; sequence-specific DNA binding; SH3 domain binding Biological Process: nucleocytoplasmic transport; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent |
NCBI Summary: | This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011] |
UniProt Code: | Q8TF68 |
NCBI GenInfo Identifier: | 296453052 |
NCBI Gene ID: | 171017 |
NCBI Accession: | Q8TF68.2 |
UniProt Secondary Accession: | Q8TF68,O15407, Q7Z722, Q8N938, |
UniProt Related Accession: | Q8TF68 |
Molecular Weight: | 50,538 Da |
NCBI Full Name: | Zinc finger protein 384 |
NCBI Synonym Full Names: | zinc finger protein 384 |
NCBI Official Symbol: | ZNF384 |
NCBI Official Synonym Symbols: | NP; CIZ; NMP4; CAGH1; ERDA2; TNRC1; CAGH1A |
NCBI Protein Information: | zinc finger protein 384 |
UniProt Protein Name: | Zinc finger protein 384 |
UniProt Synonym Protein Names: | CAG repeat protein 1; CAS-interacting zinc finger protein; Nuclear matrix transcription factor 4; Nuclear matrix protein 4; Trinucleotide repeat-containing gene 1 protein |
Protein Family: | Zinc finger protein |
UniProt Gene Name: | ZNF384 |
UniProt Entry Name: | ZN384_HUMAN |