ZIC1/ZIC2/ZIC3/ZIC4/ZIC5 Antibody (PACO05329)
- SKU:
- PACO05329
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ZIC1/ZIC2/ZIC3/ZIC4/ZIC5 Antibody (PACO05329) |
| Antibody SKU: | PACO05329 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:40000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from the Internal region of human Zic1/2/3/4/5. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ZIC1; ZIC; ZNF201; Zinc finger protein ZIC 1; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; ZIC2; Zinc finger protein ZIC 2; Zinc finger protein of the cerebellum 2; ZIC3; ZNF203; Zinc finger protein ZIC 3; Zinc finger p |
| UniProt Protein Function: | ZIC1: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3'. Belongs to the GLI C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 3q24 Cellular Component: nucleoplasm; nucleus Molecular Function:transcription factor activity Biological Process: brain development; inner ear morphogenesis; pattern specification process; positive regulation of protein import into nucleus; positive regulation of transcription, DNA-dependent; regulation of smoothened signaling pathway Disease: Craniosynostosis 6 |
| NCBI Summary: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15915 |
| NCBI GenInfo Identifier: | 209572702 |
| NCBI Gene ID: | 7545 |
| NCBI Accession: | Q15915.2 |
| UniProt Secondary Accession: | Q15915,Q2M3N1, |
| UniProt Related Accession: | Q15915 |
| Molecular Weight: | 48,309 Da |
| NCBI Full Name: | Zinc finger protein ZIC 1 |
| NCBI Synonym Full Names: | Zic family member 1 |
| NCBI Official Symbol: | ZIC1 |
| NCBI Official Synonym Symbols: | ZIC; CRS6; ZNF201 |
| NCBI Protein Information: | zinc finger protein ZIC 1 |
| UniProt Protein Name: | Zinc finger protein ZIC 1 |
| UniProt Synonym Protein Names: | Zinc finger protein 201; Zinc finger protein of the cerebellum 1 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZIC1 |
| UniProt Entry Name: | ZIC1_HUMAN |
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