XRCC6 Antibody (PACO03292)

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SKU:
PACO03292
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
WB
Antibody type:
Polyclonal
Conjugation:
Unconjugated
Frequently bought together:

Description

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Antibody Name:XRCC6 Antibody
Antibody SKU:PACO03292
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from human Ku-70 around the non-acetylation site of K539.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit;
UniProt Protein Function:Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.
UniProt Protein Details:

Protein type:Helicase; DNA repair, damage; EC 3.6.4.-; Nuclear receptor co-regulator; DNA-binding; RNA-binding; EC 4.2.99.-

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytosol; membrane; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus; transcription factor complex

Molecular Function:5'-deoxyribose-5-phosphate lyase activity; damaged DNA binding; double-stranded DNA binding; double-stranded telomeric DNA binding; protein binding; protein C-terminus binding

Biological Process: DNA ligation; DNA recombination; double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; positive regulation of interferon type I production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterotetramerization; regulation of smooth muscle cell proliferation; telomere maintenance

NCBI Summary:The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
UniProt Code:P12956
NCBI GenInfo Identifier:125729
NCBI Gene ID:2547
NCBI Accession:P12956.2
UniProt Secondary Accession:P12956,Q6FG89, Q9UCQ2, Q9UCQ3, B1AHC8,
UniProt Related Accession:P12956
Molecular Weight:65,149 Da
NCBI Full Name:X-ray repair cross-complementing protein 6
NCBI Synonym Full Names:X-ray repair cross complementing 6
NCBI Official Symbol:XRCC6  
NCBI Official Synonym Symbols:ML8; KU70; TLAA; CTC75; CTCBF; G22P1  
NCBI Protein Information:X-ray repair cross-complementing protein 6
UniProt Protein Name:X-ray repair cross-complementing protein 6
UniProt Synonym Protein Names:5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
Protein Family:X-ray repair cross-complementing protein
UniProt Gene Name:XRCC6  
UniProt Entry Name:XRCC6_HUMAN

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