XPO1 Antibody (PACO15748)
- SKU:
- PACO15748
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | XPO1 Antibody (PACO15748) |
| Antibody SKU: | PACO15748 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human XPO1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15748(XPO1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: PACO15748(XPO1 Antibody) at dilution 1/275, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15748(XPO1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. |
| Synonyms: | exportin 1 (CRM1 homolog, yeast) |
| UniProt Protein Function: | Exportin-1: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. Belongs to the exportin family. |
| UniProt Protein Details: | Protein type:Karyopherin; Nuclear import; Nucleolus; Nuclear export Chromosomal Location of Human Ortholog: 2p15 Cellular Component: kinetochore; nucleoplasm; Cajal body; nuclear membrane; intracellular membrane-bound organelle; membrane; cytoplasm; nucleolus; nuclear envelope; cytosol; ribonucleoprotein complex; nucleus; annulate lamellae Molecular Function:protein domain specific binding; protein binding; RNA binding; transporter activity; Ran GTPase binding; protein transporter activity; nucleocytoplasmic transporter activity Biological Process: response to drug; ribosomal small subunit export from nucleus; mRNA transport; viral reproduction; transforming growth factor beta receptor signaling pathway; regulation of protein catabolic process; gene expression; viral infectious cycle; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; protein export from nucleus; negative regulation of transforming growth factor beta receptor signaling pathway; ribosomal large subunit export from nucleus; regulation of protein export from nucleus |
| NCBI Summary: | This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015] |
| UniProt Code: | O14980 |
| NCBI GenInfo Identifier: | 68052989 |
| NCBI Gene ID: | 7514 |
| NCBI Accession: | O14980.1 |
| UniProt Related Accession: | O14980 |
| Molecular Weight: | 123kDa |
| NCBI Full Name: | Exportin-1 |
| NCBI Synonym Full Names: | exportin 1 |
| NCBI Official Symbol: | XPO1 |
| NCBI Official Synonym Symbols: | emb; CRM1; exp1; CRM-1 |
| NCBI Protein Information: | exportin-1 |
| UniProt Protein Name: | Exportin-1 |
| UniProt Synonym Protein Names: | Chromosome region maintenance 1 protein homolog |
| Protein Family: | Exportin |
| UniProt Gene Name: | XPO1 |
| UniProt Entry Name: | XPO1_HUMAN |
| Antibodies |
| Anti-XPO1 Antibody (CAB0299) |
| Anti-CRM1 Antibody (CAB19625) |
| Acetyl-XPO1 (K568) Antibody (PACO06083) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human XPO1 (Exportin-1) ELISA KIT (HUFI05259)
