| UniProt Protein Function: | WNK3: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family Chromosomal Location of Human Ortholog: Xp11.22 Cellular Component: adherens junction; cytoplasm; cytosol; tight junction Molecular Function:ATP binding; chloride channel inhibitor activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: negative regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; protein amino acid autophosphorylation; protein amino acid phosphorylation |
| NCBI Summary: | This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9BYP7 |
| NCBI GenInfo Identifier: | 353526307 |
| NCBI Gene ID: | 65267 |
| NCBI Accession: | Q9BYP7.3 |
| UniProt Secondary Accession: | Q9BYP7,Q5JRC1, Q6JP76, Q8TCX6, Q9HCK6, B1AKG2, |
| UniProt Related Accession: | Q9BYP7 |
| Molecular Weight: | 192,875 Da |
| NCBI Full Name: | Serine/threonine-protein kinase WNK3 |
| NCBI Synonym Full Names: | WNK lysine deficient protein kinase 3 |
| NCBI Official Symbol: | WNK3 |
| NCBI Official Synonym Symbols: | PRKWNK3 |
| NCBI Protein Information: | serine/threonine-protein kinase WNK3 |
| UniProt Protein Name: | Serine/threonine-protein kinase WNK3 |
| UniProt Synonym Protein Names: | Protein kinase lysine-deficient 3; Protein kinase with no lysine 3 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | WNK3 |
| UniProt Entry Name: | WNK3_HUMAN |
