VPS26A Antibody (PACO20864)
- SKU:
- PACO20864
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | VPS26A Antibody (PACO20864) |
| Antibody SKU: | PACO20864 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human VPS26A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20864(VPS26A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-7: 293T cells, A431 cells, Hela cells, HepG2 cells, Human fetal liver tissue, PC3 cells, Human placenta tissue,Primary antibody: PACO20864(VPS26A Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20864(VPS26A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Synonyms: | vacuolar protein sorting 26 homolog A (S. pombe) |
| UniProt Protein Function: | VPS26A: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Belongs to the VPS26 family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 10q21.1 Cellular Component: cytosol; early endosome; endosome; endosome membrane; intracellular membrane-bound organelle; retromer complex; vesicle Molecular Function:protein binding; protein transporter activity Biological Process: intracellular protein transport; regulation of macroautophagy; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway |
| NCBI Summary: | This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75436 |
| NCBI GenInfo Identifier: | 25453454 |
| NCBI Gene ID: | 9559 |
| NCBI Accession: | O75436.2 |
| UniProt Secondary Accession: | O75436,Q8TBH4, Q9H982, A8MZ56, B2RDD3, |
| UniProt Related Accession: | O75436 |
| Molecular Weight: | 28,938 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 26A |
| NCBI Synonym Full Names: | VPS26, retromer complex component A |
| NCBI Official Symbol: | VPS26A |
| NCBI Official Synonym Symbols: | HB58; PEP8A; VPS26; Hbeta58 |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 26A |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 26A |
| UniProt Synonym Protein Names: | Vesicle protein sorting 26A; hVPS26 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS26A |
| UniProt Entry Name: | VP26A_HUMAN |
| Antibodies |
| Anti-VPS26A Antibody (CAB14265) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-VPS26A Antibody (CAB14265)
