USP47 Antibody (PACO17404)
- SKU:
- PACO17404
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | USP47 Antibody (PACO17404) |
| Antibody SKU: | PACO17404 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human USP47 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17404(USP47 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A172 cell, Primary antibody: PACO17404(USP47 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17404(USP47 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene. Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase β (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. |
| Synonyms: | ubiquitin specific peptidase 47 |
| UniProt Protein Function: | USP47: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Ubiquitin-specific protease; Motility/polarity/chemotaxis; Actin-binding; Protease; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11p15.3 Cellular Component: cytoplasm; nucleus; SCF ubiquitin ligase complex Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: base-excision repair; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell growth; response to DNA damage stimulus; response to drug |
| UniProt Code: | Q96K76 |
| NCBI GenInfo Identifier: | 313104266 |
| NCBI Gene ID: | 55031 |
| NCBI Accession: | Q96K76.3 |
| UniProt Secondary Accession: | Q96K76,Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1, B3KXF5 E9PM46, |
| UniProt Related Accession: | Q96K76 |
| Molecular Weight: | 154,697 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 47 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 47 |
| NCBI Official Symbol: | USP47 |
| NCBI Official Synonym Symbols: | TRFP |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 47 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 47 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP47 |
| UniProt Entry Name: | UBP47_HUMAN |
| Antibodies |
| Anti-USP47 Antibody (CAB15461) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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