| UniProt Protein Function: | UBE2J2: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; Ubiquitin conjugating system; EC 6.3.2.19; Endoplasmic reticulum; Ubiquitin ligase; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.33 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ATP binding; ligase activity Biological Process: ER-associated protein catabolic process; protein polyubiquitination; response to unfolded protein |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N2K1 |
| NCBI GenInfo Identifier: | 251757431 |
| NCBI Gene ID: | 118424 |
| NCBI Accession: | Q8N2K1.3 |
| UniProt Secondary Accession: | Q8N2K1,Q504T9, Q96N26, Q96T84, A8MYC7, |
| UniProt Related Accession: | Q8N2K1 |
| Molecular Weight: | 259 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 J2 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2, J2 |
| NCBI Official Symbol: | UBE2J2 |
| NCBI Official Synonym Symbols: | NCUBE2; NCUBE-2; PRO2121 |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 J2; yeast UBC6 homolog; ubiquitin conjugating enzyme 6; ubiquitin conjugating enzyme E2, J2; non-canonical ubiquitin-conjugating enzyme 2; ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 J2 |
| UniProt Synonym Protein Names: | Non-canonical ubiquitin-conjugating enzyme 2; NCUBE-2 |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2J2 |
| UniProt Entry Name: | UB2J2_HUMAN |
