TYK2 Antibody (PACO01666)
- SKU:
- PACO01666
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TYK2 Antibody |
| Antibody SKU: | PACO01666 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Monkey |
| Immunogen: | synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Y1054. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TYK2; Non-receptor tyrosine-protein kinase TYK2 |
| UniProt Protein Function: | Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation Disease: Immunodeficiency 35 |
| NCBI Summary: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29597 |
| NCBI GenInfo Identifier: | 56405328 |
| NCBI Gene ID: | 7297 |
| NCBI Accession: | P29597.3 |
| UniProt Secondary Accession: | P29597,Q6QB10, Q96CH0, |
| UniProt Related Accession: | P29597 |
| Molecular Weight: | 1187 |
| NCBI Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
| NCBI Synonym Full Names: | tyrosine kinase 2 |
| NCBI Official Symbol: | TYK2 |
| NCBI Official Synonym Symbols: | JTK1; IMD35 |
| NCBI Protein Information: | non-receptor tyrosine-protein kinase TYK2 |
| UniProt Protein Name: | Non-receptor tyrosine-protein kinase TYK2 |
| Protein Family: | Non-receptor tyrosine-protein kinase |
| UniProt Gene Name: | TYK2 |
| UniProt Entry Name: | TYK2_HUMAN |
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