TRIM22 Antibody (PACO20693)
- SKU:
- PACO20693
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | TRIM22 Antibody (PACO20693) |
| Antibody SKU: | PACO20693 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human TRIM22 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: A172 cells, Primary antibody: PACO20693(TRIM22 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20693(TRIM22 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. |
| Synonyms: | tripartite motif containing 22 |
| UniProt Protein Function: | TRIM22: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 11p15 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein binding, bridging; protein kinase binding; transcription corepressor activity; transcription factor activity Biological Process: activation of NF-kappaB transcription factor; immune response; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor activity; regulation of protein localization; regulation of transcription, DNA-dependent; response to virus |
| NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q8IYM9 |
| NCBI GenInfo Identifier: | 47606181 |
| NCBI Gene ID: | 10346 |
| NCBI Accession: | Q8IYM9.1 |
| UniProt Secondary Accession: | Q8IYM9,Q05CQ0, Q15521, |
| UniProt Related Accession: | Q8IYM9 |
| Molecular Weight: | 56,429 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase TRIM22 |
| NCBI Synonym Full Names: | tripartite motif containing 22 |
| NCBI Official Symbol: | TRIM22 |
| NCBI Official Synonym Symbols: | RNF94; STAF50; GPSTAF50 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM22 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM22 |
| UniProt Synonym Protein Names: | 50 kDa-stimulated trans-acting factor; RING finger protein 94; Staf-50; Tripartite motif-containing protein 22 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | TRIM22 |
| UniProt Entry Name: | TRI22_HUMAN |
| Antibodies | ELISA Kits |
| Anti-TRIM22 Antibody (CAB5508) | Human TRIM22 ELISA Kit |
| Human E3 ubiquitin-protein ligase TRIM22 (TRIM22) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-TRIM22 Antibody (CAB5508)
Human E3 ubiquitin-protein ligase TRIM22 (TRIM22) ELISA Kit
Human TRIM22 ELISA Kit
Human TP53 antibody(p53 antibody) ELISA Kit
