Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
Product Name:
Transferrin Receptor/TFRC Recombinant Protein (RPES2247)
Product Code:
RPES2247
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
Transferrin receptor protein 1, TR, TfR, Trfr, T9, p90,CD71,T9,TFR,TFR,TRFR
Accession:
NP_003225.2
Sequence:
Cys 89-Phe 760
Fusion tag:
N-His
Activity:
Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 µg/ml (100 ?l/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the extracellular domain of human TFRC (NP_003225.2) (Cys 89-Phe 760) was expressed with a polyhistidine tag at the N-terminus.
Purity:
> 85 % as determined by reducing SDS-PAGE.
Mol Mass:
77.4 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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