| UniProt Protein Function: | TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22 Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane Molecular Function:single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity; drug binding Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-beta biosynthetic process; positive regulation of innate immune response; toll-like receptor signaling pathway; innate immune response; immunoglobulin mediated immune response; toll-like receptor 9 signaling pathway; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NR97 |
| NCBI GenInfo Identifier: | 20140873 |
| NCBI Gene ID: | 51311 |
| NCBI Accession: | Q9NR97.1 |
| UniProt Secondary Accession: | Q9NR97,Q495P4, Q6UXL6, Q9NYG9, B3Y654, D1CS70, D1CS76 |
| UniProt Related Accession: | Q9NR97 |
| Molecular Weight: | Calculated MW:1195Da/121kDaOberverd MW: 115kDa |
| NCBI Full Name: | Toll-like receptor 8 |
| NCBI Synonym Full Names: | toll-like receptor 8 |
| NCBI Official Symbol: | TLR8 |
| NCBI Official Synonym Symbols: | CD288 |
| NCBI Protein Information: | toll-like receptor 8 |
| UniProt Protein Name: | Toll-like receptor 8 |
| UniProt Synonym Protein Names: | CD_antigen: CD288 |
| Protein Family: | Toll-like receptor |
| UniProt Gene Name: | TLR8 |
| UniProt Entry Name: | TLR8_HUMAN |
