Thyroid Hormone Receptor beta Transcription Factor Activity Assay
- SKU:
- TFAB00174
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- Thyroid Hormone Receptor beta
- Reactivity:
- Human
- Mouse
- Rat
Description
Thyroid Hormone Receptor beta Transcription Factor Activity Assay
The Thyroid Hormone Receptor Beta Transcription Factor Activity Assay is a powerful tool for studying the activity of the thyroid hormone receptor beta and its role in gene transcription regulation. This assay kit is designed for accurate and reliable detection of transcription factor activity in various samples, including cell lysates and tissue homogenates.Thyroid hormone receptor beta is a key regulator of metabolism, growth, and development, and dysregulation of its activity has been implicated in various diseases, including thyroid disorders and metabolic syndromes. Understanding the mechanisms of thyroid hormone receptor beta activity can provide valuable insights into the pathophysiology of these conditions and aid in the development of novel therapeutic strategies.
With its high sensitivity and specificity, the Thyroid Hormone Receptor Beta Transcription Factor Activity Assay ensures precise measurement of transcription factor activity, allowing researchers to investigate the molecular pathways involved in thyroid hormone signaling. Whether studying basic biology or exploring potential drug targets, this assay kit is a valuable tool for advancing research in the field of thyroid hormone receptor biology.
| Product Name: | Thyroid Hormone Receptor beta Transcription Factor Activity Assay |
| Product Code: | TFAB00174 |
| Target: | Thyroid Hormone Receptor beta |
| Synonyms: | Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Thyroid Hormone Receptor beta transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | TR-beta1: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Homolog of the viral oncogene erbB. Two splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Nuclear receptor; DNA-binding Chromosomal Location of Human Ortholog: 3p24.2 Cellular Component: nucleoplasm; nuclear chromatin; nucleus Molecular Function:protein binding; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; chromatin DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription corepressor activity; transcription factor activity Biological Process: negative regulation of female receptivity; transcription initiation from RNA polymerase II promoter; organ morphogenesis; sensory perception of sound; intracellular receptor-mediated signaling pathway; female courtship behavior; transcription, DNA-dependent; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction Disease: Thyroid Hormone Resistance, Selective Pituitary; Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10828 |
| NCBI GenInfo Identifier: | 586092 |
| NCBI Gene ID: | 7068 |
| NCBI Accession: | P10828.2 |
| UniProt Secondary Accession: | P10828,P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41, B3KU79 |
| UniProt Related Accession: | P10828 |
| Molecular Weight: | 461 |
| NCBI Full Name: | Thyroid hormone receptor beta |
| NCBI Synonym Full Names: | thyroid hormone receptor, beta |
| NCBI Official Symbol: | THRB |
| NCBI Official Synonym Symbols: | GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA |
| NCBI Protein Information: | thyroid hormone receptor beta; oncogene ERBA2; nuclear receptor subfamily 1 group A member 2; thyroid hormone nuclear receptor beta variant 1; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) |
| UniProt Protein Name: | Thyroid hormone receptor beta |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta |
| Protein Family: | Thyroid hormone receptor |
| UniProt Gene Name: | THRB |
| UniProt Entry Name: | THB_HUMAN |
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