| UniProt Protein Function: | TEAD1: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. Interacts with YAP1 and WWTR1/TAZ. Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm Molecular Function:protein binding; DNA binding; transcription factor activity Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; gene expression Disease: Sveinsson Chorioretinal Atrophy |
| NCBI Summary: | This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010] |
| UniProt Code: | P28347 |
| NCBI GenInfo Identifier: | 3041733 |
| NCBI Gene ID: | 7003 |
| NCBI Accession: | P28347.2 |
| UniProt Secondary Accession: | P28347,A4FUP2, E7EV65, |
| UniProt Related Accession: | P28347 |
| Molecular Weight: | 426 |
| NCBI Full Name: | Transcriptional enhancer factor TEF-1 |
| NCBI Synonym Full Names: | TEA domain family member 1 (SV40 transcriptional enhancer factor) |
| NCBI Official Symbol: | TEAD1 |
| NCBI Official Synonym Symbols: | AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1 |
| NCBI Protein Information: | transcriptional enhancer factor TEF-1; protein GT-IIC; transcription factor 13; transcriptional enhancer factor 1 |
| UniProt Protein Name: | Transcriptional enhancer factor TEF-1 |
| UniProt Synonym Protein Names: | NTEF-1; Protein GT-IIC; TEA domain family member 1; TEAD-1; Transcription factor 13; TCF-13 |
| Protein Family: | Transcriptional enhancer factor |
| UniProt Gene Name: | TEAD1 |
| UniProt Entry Name: | TEAD1_HUMAN |
