TBX3/TBX2 Antibody (PACO01593)
- SKU:
- PACO01593
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TBX3/TBX2 Antibody |
| Antibody SKU: | PACO01593 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human TBX2/3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TBX3; T-box transcription factor TBX3; T-box protein 3; TBX2; T-box transcription factor TBX2; T-box protein 2 |
| UniProt Protein Function: | TBX3: Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS). UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q24.21 Cellular Component: nucleus Molecular Function:protein binding; sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; limbic system development; positive regulation of transcription, DNA-dependent; negative regulation of epithelial cell differentiation; palate development; negative regulation of transcription from RNA polymerase II promoter; female genitalia development; forelimb morphogenesis; mammary gland development; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; male genitalia development; heart looping; skeletal development; luteinizing hormone secretion; blood vessel development; specification of organ position; transcription, DNA-dependent; in utero embryonic development; stem cell maintenance; positive regulation of cell cycle; cell aging; regulation of transcription from RNA polymerase II promoter; organ morphogenesis; mesoderm morphogenesis; follicle-stimulating hormone secretion; embryonic digit morphogenesis; negative regulation of myoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis Disease: Ulnar-mammary Syndrome |
| NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15119 |
| NCBI GenInfo Identifier: | 28381401 |
| NCBI Gene ID: | 6926 |
| NCBI Accession: | O15119.4 |
| UniProt Secondary Accession: | O15119,Q8TB20, Q9UKF8, |
| UniProt Related Accession: | O15119 |
| Molecular Weight: | 743 |
| NCBI Full Name: | T-box transcription factor TBX3 |
| NCBI Synonym Full Names: | T-box 3 |
| NCBI Official Symbol: | TBX3 |
| NCBI Official Synonym Symbols: | UMS; XHL; TBX3-ISO |
| NCBI Protein Information: | T-box transcription factor TBX3; T-box protein 3; bladder cancer related protein XHL |
| UniProt Protein Name: | T-box transcription factor TBX3 |
| Protein Family: | T-box transcription factor |
| UniProt Gene Name: | TBX3 |
| UniProt Entry Name: | TBX3_HUMAN |
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