tal1 Antibody (PACO53778)
- SKU:
- PACO53778
- Product type:
- Antibody
- Reactivity:
- Zebrafish
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | tal1 Antibody (PACO53778) |
| Antibody SKU: | PACO53778 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Zebrafish |
| Immunogen: | Recombinant Zebrafish T-cell acute lymphocytic leukemia protein 1 homolog protein (1-324AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Zebrafish tissue 20μg, 10μg. All lanes: tal1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 36, 23 kDa. Observed band size: 36 kDa. |
| Background: | Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform α and isoform β are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development. |
| Synonyms: | T-cell acute lymphocytic leukemia protein 1 homolog (TAL-1) (Stem cell protein) (zSCL), tal1, scl tal-1 |
| UniProt Protein Function: | Transcription factor that plays a pivotal role in hemopoietic and endothelial development, acting synergistically with lmo2 and downstream of clo. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hemopoietic induction cues such as gata1, tal1/scl-lmo2-induced hemangioblasts differentiate into endothelial cells. Isoform alpha and isoform beta are redundant for the initiation of primitive hemopoiesis but have distinct roles in the regulation of primitive erythroid differentiation and definitive hemopoietic stem cell specification, most likely due to differences in expression levels. Specification of definitive hemopoietic stem cells requires isoform beta. DNA binding is required for erythroid maturation, but not for its other hemopoietic functions. Endothelial roles include development of the dorsal aorta, the site of definitive hemopoiesis in the embryo. Required for angiogenesis but not angioblast specification. Has an additional role in endocardium formation during heart development. May play a role in central nervous system development. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O93507 |
| NCBI GenInfo Identifier: | 55742470 |
| NCBI Gene ID: | 30766 |
| NCBI Accession: | NP_998402.1 |
| UniProt Secondary Accession: | O93507,O57562, Q90W24, A4UTQ6 |
| UniProt Related Accession: | O93507 |
| Molecular Weight: | 22,925 Da |
| NCBI Full Name: | T-cell acute lymphocytic leukemia protein 1 homolog |
| NCBI Synonym Full Names: | T-cell acute lymphocytic leukemia 1 |
| NCBI Official Symbol: | tal1 |
| NCBI Official Synonym Symbols: | scl; tal-1; SCL-beta; scl/tal1; SCL-alpha; zgc:85605 |
| NCBI Protein Information: | T-cell acute lymphocytic leukemia protein 1 homolog |
| UniProt Protein Name: | T-cell acute lymphocytic leukemia protein 1 homolog |
| UniProt Synonym Protein Names: | Stem cell protein; zSCL |
| Protein Family: | Transaldolase |
| UniProt Gene Name: | tal1 |
| UniProt Entry Name: |
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