| UniProt Protein Function: | TAF1A: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q42 Cellular Component: intracellular membrane-bound organelle; microtubule cytoskeleton; nucleoplasm; nucleus; RNA polymerase I transcription factor complex Molecular Function:protein binding Biological Process: positive regulation of gene expression, epigenetic; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter |
| NCBI Summary: | This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011] |
| UniProt Code: | Q15573 |
| NCBI GenInfo Identifier: | 74739864 |
| NCBI Gene ID: | 9015 |
| NCBI Accession: | Q15573.1 |
| UniProt Secondary Accession: | Q15573,Q9NWA1, B2RDZ8, D3DTB7, |
| UniProt Related Accession: | Q15573 |
| Molecular Weight: | 39,615 Da |
| NCBI Full Name: | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| NCBI Synonym Full Names: | TATA-box binding protein associated factor, RNA polymerase I subunit A |
| NCBI Official Symbol: | TAF1A |
| NCBI Official Synonym Symbols: | SL1; RAFI48; TAFI48; MGC:17061 |
| NCBI Protein Information: | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| UniProt Protein Name: | TATA box-binding protein-associated factor RNA polymerase I subunit A |
| UniProt Synonym Protein Names: | RNA polymerase I-specific TBP-associated factor 48 kDa; TAFI48; TATA box-binding protein-associated factor 1A; TBP-associated factor 1A; Transcription factor SL1; Transcription initiation factor SL1/TIF-IB subunit A |
| Protein Family: | TATA box-binding protein-associated factor |
| UniProt Gene Name: | TAF1A |
| UniProt Entry Name: | TAF1A_HUMAN |
