SUCLA2 Antibody (PACO45581)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO45581
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SUCLA2 Antibody (PACO45581) |
Antibody SKU: | PACO45581 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial protein (1-180AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: SUCLA2 antibody at 1.75µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Jurkat whole cell lysate. Lane 3: A549 whole cell lysate. Lane 4: 293T whole cell lysate. Lane 5: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 51, 49 kDa. Observed band size: 51 kDa.. | |
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45581 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO45581 at dilution of 1:100. |
Background: | Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA. |
Synonyms: | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA), SUCLA2 |
UniProt Protein Function: | SCS-beta: a mitochondrial enzyme that catalyzes the phosphorylation of NTP, where N = adenosine or guanosine, in the tricarboxylic acid cycle. Catalyzes the following: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; EC 6.2.1.5; Carbohydrate Metabolism - propanoate; Ligase Chromosomal Location of Human Ortholog: 13q14.2 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:protein binding; metal ion binding; succinate-CoA ligase (ADP-forming) activity; ATP binding Biological Process: succinate metabolic process; cellular metabolic process; succinyl-CoA pathway; succinyl-CoA metabolic process; tricarboxylic acid cycle Disease: Mitochondrial Dna Depletion Syndrome 5 (encephalomyopathic With Or Without Methylmalonic Aciduria) |
NCBI Summary: | Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9P2R7 |
NCBI GenInfo Identifier: | 94730427 |
NCBI Gene ID: | 8803 |
NCBI Accession: | Q9P2R7.3 |
UniProt Secondary Accession: | Q9P2R7,O95194, Q5T9Q4, Q5T9Q6, Q9NV21, Q9NVP7, B2RDE7 |
UniProt Related Accession: | Q9P2R7 |
Molecular Weight: | 48,040 Da |
NCBI Full Name: | Succinyl-CoA ligase |
NCBI Synonym Full Names: | succinate-CoA ligase, ADP-forming, beta subunit |
NCBI Official Symbol: | SUCLA2 |
NCBI Official Synonym Symbols: | A-BETA; MTDPS5; SCS-betaA |
NCBI Protein Information: | succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial |
UniProt Protein Name: | Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial |
UniProt Synonym Protein Names: | ATP-specific succinyl-CoA synthetase subunit beta; Renal carcinoma antigen NY-REN-39; Succinyl-CoA synthetase beta-A chain; SCS-betaA |
UniProt Gene Name: | SUCLA2 |
UniProt Entry Name: | SUCB1_HUMAN |