SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0635)

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SKU:
RPES0635
Product type:
Recombinant Protein
Host species:
Baculovirus-Insect Cells
Reactivity:
Human
Frequently bought together:

Description

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SPHK1/Sphingosine Kinase 1 Recombinant Protein

SPHK1; also known as sphingosine Kinase 1; catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation; survival; migration; cytoskeletal organization; and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory; antiapoptotic; and immune processes.

Product Name:SPHK1/Sphingosine Kinase 1 Recombinant Protein (RPES0635)
Product Code:RPES0635
Size:20µg
Species:Human
Expressed Host:Baculovirus-Insect Cells
Synonyms:SPHK,SPHK1,SPK
Accession:Q9NYA1-1
Sequence:Met 1-Leu 384
Fusion tag:
Activity:The specific activity was determined to be 1028 nmol/min/mg using Sphingosine Kinase Substrate as substrate.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:42.7 kDa
AP Mol Mass:46 kDa
Formulation:Supplied as sterile 20mM Tris; 500mM NaCl; 10% glycerol; pH 8.0
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

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