SOD1/Superoxide Dismutase 1 Recombinant Protein (RPES0249)

(No reviews yet) Write a Review
SKU:
RPES0249
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
Frequently bought together:

Description

system_update_alt데이터시트

SOD1/Superoxide Dismutase 1 Recombinant Protein

SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. SOD1 destroys radicals which are normally produced within the cells and which are toxic to biological systems. Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1). ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.

Product Name:SOD1/Superoxide Dismutase 1 Recombinant Protein (RPES0249)
Product Code:RPES0249
Size:50µg
Species:Human
Expressed Host:E.coli
Synonyms:Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1, hSod1,ALS,ALS1,HEL-S-44,homodimer,hSod1,IPOA
Accession:NP_000445.1
Sequence:Ala 2-Gln 154
Fusion tag:N-His
Endotoxin:Please contact us for more information.
Protein Construction:A DNA sequence encoding the human SOD1 (NP_000445.1) (Ala 2-Gln 154) was expressed, with a polyhistide tag at the N-terminus.
Purity:> 97 % as determined by reducing SDS-PAGE.
Mol Mass:16.8 kDa
AP Mol Mass:20 kDa
Formulation:Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

0 Reviews

View AllClose

Related Products