| UniProt Protein Function: | SLC4A7: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. Belongs to the anion exchanger (TC 2.A.31) family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 3p24.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:anion transmembrane transporter activity; sodium:bicarbonate symporter activity Biological Process: auditory receptor cell development; bicarbonate transport; regulation of intracellular pH |
| NCBI Summary: | This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q9Y6M7 |
| NCBI GenInfo Identifier: | 229462789 |
| NCBI Gene ID: | 9497 |
| NCBI Accession: | Q9Y6M7.2 |
| UniProt Secondary Accession: | Q9Y6M7,A6NIA8, B2CI53, B5M449, B5M451, B5M452, B5M453 B6DY52, B6DY53, C9JST9, D3K174, D3K175, |
| UniProt Related Accession: | Q9Y6M7 |
| Molecular Weight: | 136kDa |
| NCBI Full Name: | Sodium bicarbonate cotransporter 3 |
| NCBI Synonym Full Names: | solute carrier family 4 member 7 |
| NCBI Official Symbol: | SLC4A7 |
| NCBI Official Synonym Symbols: | NBC2; NBC3; SBC2; NBCN1; SLC4A6 |
| NCBI Protein Information: | sodium bicarbonate cotransporter 3 |
| UniProt Protein Name: | Sodium bicarbonate cotransporter 3 |
| UniProt Synonym Protein Names: | Electroneutral Na/HCO(3) cotransporter; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7 |
| Protein Family: | Sodium bicarbonate cotransporter |
| UniProt Gene Name: | SLC4A7 |
