SLC40A1 Antibody (PACO20508)
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주문- SKU:
- PACO20508
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | SLC40A1 Antibody (PACO20508) |
Antibody SKU: | PACO20508 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Synthetic peptide of human SLC40A1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20508(SLC40A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). |
Synonyms: | solute carrier family 40 (iron-regulated transporter), member 1 |
UniProt Protein Function: | SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family Chromosomal Location of Human Ortholog: 2q32 Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular Molecular Function:iron ion transmembrane transporter activity; protein binding Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; lymphocyte homeostasis; transmembrane transport; negative regulation of apoptosis Disease: Hemochromatosis, Type 4 |
NCBI Summary: | The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NP59 |
NCBI GenInfo Identifier: | 67633296 |
NCBI Gene ID: | 30061 |
NCBI Accession: | AAY78556.1 |
UniProt Secondary Accession: | Q9NP59,Q6FI62, Q7Z4F8, Q8IVB2, Q9NRL0, |
UniProt Related Accession: | Q9NP59 |
Molecular Weight: | 62,542 Da |
NCBI Full Name: | ferroportin 1 variant I, partial |
NCBI Synonym Full Names: | solute carrier family 40 (iron-regulated transporter), member 1 |
NCBI Official Symbol: | SLC40A1 |
NCBI Official Synonym Symbols: | FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3 |
NCBI Protein Information: | solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 |
UniProt Protein Name: | Solute carrier family 40 member 1 |
UniProt Synonym Protein Names: | Ferroportin-1; Iron-regulated transporter 1 |
UniProt Gene Name: | SLC40A1 |
UniProt Entry Name: | S40A1_HUMAN |
Antibodies | ELISA Kits |
Anti-SLC40A1 Antibody (CAB14884) | Human SLC40A1 / Ferroportin-1 ELISA Kit |
Anti-SLC40A1 Antibody (CAB14885) | Human Solute carrier family 40 member 1 (SLC40A1) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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