SLC30A10 Antibody (PACO46666)
- SKU:
- PACO46666
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | SLC30A10 Antibody (PACO46666) |
| Antibody SKU: | PACO46666 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:100-1:500, IF:1:50-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Zinc transporter 10 protein (58-278AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: SLC30A10 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53, 27, 25 kDa. Observed band size: 53 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO46666 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO46666 at dilution of 1:100. |
| Background: | Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. |
| Synonyms: | Zinc transporter 10 (ZnT-10) (Manganese transporter SLC30A10) (Solute carrier family 30 member 10), SLC30A10, ZNT10 ZNT8 |
| UniProt Protein Function: | SLC30A10: May be involved in zinc transport out of the cell, being a zinc-efflux transporter. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1q41Cellular Component: plasma membraneMolecular Function: zinc ion transmembrane transporter activityBiological Process: manganese ion transport; response to zinc ionDisease: Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q6XR72 |
| NCBI GenInfo Identifier: | 311033506 |
| NCBI Gene ID: | 55532 |
| NCBI Accession: | Q6XR72.2 |
| UniProt Secondary Accession: | Q6XR72,Q49AL9, Q9NPW0 |
| UniProt Related Accession: | Q6XR72 |
| Molecular Weight: | 24,009 Da |
| NCBI Full Name: | Zinc transporter 10 |
| NCBI Synonym Full Names: | solute carrier family 30 member 10 |
| NCBI Official Symbol: | SLC30A10 |
| NCBI Official Synonym Symbols: | ZNT8; ZRC1; HMDPC; ZNT10; ZnT-10; HMNDYT1 |
| NCBI Protein Information: | zinc transporter 10 |
| UniProt Protein Name: | Zinc transporter 10 |
| UniProt Synonym Protein Names: | Solute carrier family 30 member 10 |
| Protein Family: | Zinc transporter |
| UniProt Gene Name: | SLC30A10 |
| UniProt Entry Name: | ZNT10_HUMAN |
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