SLC27A4 Antibody (PACO43510)
- SKU:
- PACO43510
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | SLC27A4 Antibody (PACO43510) |
| Antibody SKU: | PACO43510 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Long-chain fatty acid, transport protein 4 protein (494-643AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO43510 at dilution of 1:100. |
| Background: | Involved in translocation of long-chain fatty acid, (LFCA) across the plasma membrane. Appears to be the principal fatty acid, transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acid, (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. |
| Synonyms: | Long-chain fatty acid, transport protein 4 (FATP-4) (Fatty acid, transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4), SLC27A4, ACSVL4 FATP4 |
| UniProt Protein Function: | SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; EC 6.2.1.-; Ligase Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; integral to membrane; plasma membrane Molecular Function:fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity Biological Process: long-chain fatty acid transport; skin development; transport; very-long-chain fatty acid catabolic process; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient Disease: Ichthyosis Prematurity Syndrome |
| NCBI Summary: | This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010] |
| UniProt Code: | Q6P1M0 |
| NCBI GenInfo Identifier: | 40807357 |
| NCBI Gene ID: | 10999 |
| NCBI Accession: | NP_005085.2 |
| UniProt Related Accession: | Q6P1M0 |
| Molecular Weight: | Observed: 70 kDaPredicted: 73 kDa |
| NCBI Full Name: | long-chain fatty acid transport protein 4 |
| NCBI Synonym Full Names: | solute carrier family 27 member 4 |
| NCBI Official Symbol: | SLC27A4 |
| NCBI Official Synonym Symbols: | IPS; FATP4; ACSVL4 |
| NCBI Protein Information: | long-chain fatty acid transport protein 4 |
| UniProt Protein Name: | Long-chain fatty acid transport protein 4 |
| UniProt Synonym Protein Names: | Solute carrier family 27 member 4 |
| UniProt Gene Name: | SLC27A4 |
| UniProt Entry Name: | S27A4_HUMAN |
| Antibodies |
| Anti-SLC27A4 Antibody (CAB16101) |
| Anti-SLC27A4 Antibody (CAB16102) |
| Anti-SLC27A4 Antibody (CAB7579) |
| SLC27A4 Antibody (PACO03372) |
| SLC27A4 Antibody (PACO12278) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-SLC27A4 Antibody (CAB16101)
Anti-SLC27A4 Antibody (CAB7579)
Anti-SLC27A4 Antibody (CAB16102)
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