SLC27A4 Antibody (PACO12278)

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SKU:
PACO12278
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
WB
Application:
IHC
Antibody type:
Polyclonal
Conjugation:
Unconjugated
Frequently bought together:

Description

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Antibody Name:SLC27A4 Antibody (PACO12278)
Antibody SKU:PACO12278
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse
Immunogen:Human SLC27A4
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:solute carrier family 27 (fatty acid, transporter), member 4;SLC27A4;ACSVL4;FATP4 ;
UniProt Protein Function:SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; EC 6.2.1.-; Ligase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; integral to membrane; plasma membrane

Molecular Function:fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity

Biological Process: long-chain fatty acid transport; skin development; transport; very-long-chain fatty acid catabolic process; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient

Disease: Ichthyosis Prematurity Syndrome

NCBI Summary:This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
UniProt Code:Q6P1M0
NCBI GenInfo Identifier:40807357
NCBI Gene ID:10999
NCBI Accession:NP_005085.2
UniProt Related Accession:Q6P1M0
Molecular Weight:Observed: 70 kDaPredicted: 73 kDa
NCBI Full Name:long-chain fatty acid transport protein 4
NCBI Synonym Full Names:solute carrier family 27 member 4
NCBI Official Symbol:SLC27A4  
NCBI Official Synonym Symbols:IPS; FATP4; ACSVL4  
NCBI Protein Information:long-chain fatty acid transport protein 4
UniProt Protein Name:Long-chain fatty acid transport protein 4
UniProt Synonym Protein Names:Solute carrier family 27 member 4
UniProt Gene Name:SLC27A4  
UniProt Entry Name:S27A4_HUMAN

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