Sarilumab (Anti-IL-6) Biosimilar In Vivo Antibody (Fc Reduced)

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SKU:

IVMB0220

Product Type:

Biosimilar In Vivo Antibody

Antibody Type:

Monoclonal Antibody

Protein:

IL-6

Clone:

Hu137

Isotype:

IgG1 kappa

Reactivity:

Human

Synonyms:

Interleukin-6, CDF, HGF, HSF, BSF2, BSF-2, IFNB2, IFN-beta-2

Description

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Product Name:	Sarilumab (Anti-IL-6) Biosimilar In Vivo Antibody (Fc Reduced)
Product Code:	IVMB0220
Clone:	Hu137
Protein:	IL-6
Product Type:	Biosimilar Recombinant Human Monoclonal Antibody
Synonyms:	Interleukin-6, CDF, HGF, HSF, BSF2, BSF-2, IFNB2, IFN-beta-2
Isotype:	Human IgG1κ
Reactivity:	Human
Applications:	B, ELISA, FA, FC, IHC, N, WB
Formulation:	This biosimilar antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Applications:	B, ELISA, FA, FC, IHC, N, WB
Recommended Usage:	FC The suggested concentration for Alemtuzumab biosimilar antibody for staining cells in flow cytometry is ≤ 0.25 µg per 10⁶ in a volume of 100 µl. Titration of the reagent is recommended for optimal performance for each application.
Reactivity:	Human

Specificity:	This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Sarilumab. Sarilumab binds to the transmembrane and soluble forms of the IL-6 receptor. This product is for research use only.
Antigen Distribution:	IL-6R is ubiquitously expressed.
Concentration:	≥ 5.0 mg/ml
Endotoxin Level:	< 1.0 EU/mg as determined by the LAL method
Purity:	≥95% monomer by analytical SEC
Formulation:	This biosimilar antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Preparation:	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:	Functional grade biosimilar antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Protein:	IL-6
Research Area:	Cell Biology, Immunology, Innate Immunity, Neuroscience