UniProt Protein Function: | RNA ligase that mediates the joining of broken tRNA-like stem-loop structures in case of tRNA damage. Probably participates to tRNA restriction-repair by ligating broken tRNA-like stem-loop structures with 2',3'-cyclic phosphate and 5'-OH ends to form a splice junction with a 2'-OH, 3',5'-phosphodiester, a step that requires GTP (PubMed:21224389, PubMed:22730297). Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-PO4 (or cyclic-PO4) and 5'-OH ends that cannot be sealed by classical DNA ligases (PubMed:24218597). |
UniProt Protein Details: | |
NCBI Summary: | RtcB has similarity to proteins found in Eucarya, Bacteria, and Archaea . [More information is available at EcoCyc: G7751]. |
UniProt Code: | P46850 |
NCBI GenInfo Identifier: | 16131295 |
NCBI Gene ID: | 947929 |
NCBI Accession: | NP_417879.1 |
UniProt Secondary Accession: | P46850,P76690, Q2M785 |
UniProt Related Accession: | P46850 |
Molecular Weight: | |
NCBI Full Name: | RNA-splicing ligase |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | rtcB |
NCBI Official Synonym Symbols: | ECK3407; JW3384; yhgL |
NCBI Protein Information: | RNA-splicing ligase |
UniProt Protein Name: | RNA-splicing ligase RtcB |
UniProt Synonym Protein Names: | |
Protein Family: | RNA-splicing ligase |
UniProt Gene Name: | rtcB |
UniProt Entry Name: | RTCB_ECOLI |