RRAGB Antibody (PACO03338)
- SKU:
- PACO03338
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | RRAGB Antibody |
| Antibody SKU: | PACO03338 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human Rag B. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | RRAGB; Ras-related GTP-binding protein B; Rag B; RagB |
| UniProt Protein Function: | RRAGB: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: Xp11.21Cellular Component: cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; lysosomal membrane; lysosome; nucleusMolecular Function: GTP binding; GTPase activity; guanyl ribonucleotide binding; protein bindingBiological Process: cell cycle arrest; cellular response to amino acid starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of TOR signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5VZM2 |
| NCBI GenInfo Identifier: | 74747821 |
| NCBI Gene ID: | 10325 |
| NCBI Accession: | Q5VZM2.1 |
| UniProt Secondary Accession: | Q5VZM2,Q15348, Q8N3T0, A8K042 |
| UniProt Related Accession: | Q5VZM2 |
| Molecular Weight: | 40,172 Da |
| NCBI Full Name: | Ras-related GTP-binding protein B |
| NCBI Synonym Full Names: | Ras related GTP binding B |
| NCBI Official Symbol: | RRAGB |
| NCBI Official Synonym Symbols: | RAGB; bA465E19.1 |
| NCBI Protein Information: | ras-related GTP-binding protein B |
| UniProt Protein Name: | Ras-related GTP-binding protein B |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | RRAGB |
| UniProt Entry Name: | RRAGB_HUMAN |
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