Rhesus/Canine BMP-2 Recombinant Protein (RPES1004)
- SKU:
- RPES1004
- Product type:
- Recombinant Protein
- Host species:
- HEK293 Cells
- Reactivity:
- Human
Frequently bought together:
Description
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Rhesus/Canine BMP-2 Recombinant Protein
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 protein may play an important role in the progression of glioma.
| Product Name: | Rhesus/Canine BMP-2 Recombinant Protein (RPES1004) |
| Product Code: | RPES1004 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | BDA2,BDA2A,BMP-2,BMP2A,BMP2 |
| Accession: | NP_001191.1 |
| Sequence: | Gln 283-Arg 396 |
| Fusion tag: | C-Fc |
| Activity: | 1.Measured by its ability to bind recombinant human Nog-Fc in a functional ELISA.2. Measured by its ability to bind recombinant human ALK3-Fch in a functional ELISA.3. Measured by its ability to bind recombinant mouse ALK3-Fch in a functional ELISA.4. Measured by its ability to bind recombinant human BMPR-II-Fc in a functional ELISA. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln 283-Arg 396) was fused with the Fc region of human IgG1 at the C-terminus. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 39.5 kDa |
| Formulation: | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.51. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.2. Please contact us for any concerns or special requirements. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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