RGS19 Antibody (PACO49946)
- SKU:
- PACO49946
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | RGS19 Antibody (PACO49946) |
| Antibody SKU: | PACO49946 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO49946 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO49946 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO49946 at dilution of 1:100. |
| Background: | Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form. Binds to G-α subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-α is inhibited by phosphorylation and palmitoylation of the G-protein. |
| Synonyms: | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP), RGS19, GAIP GNAI3IP |
| UniProt Protein Function: | RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density Molecular Function:beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction |
| NCBI Summary: | G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49795 |
| NCBI GenInfo Identifier: | 1730186 |
| NCBI Gene ID: | 10287 |
| NCBI Accession: | P49795.1 |
| UniProt Secondary Accession: | P49795,Q53XN0, Q8TD60, A8K216, E1P5G9, |
| UniProt Related Accession: | P49795 |
| Molecular Weight: | 24,636 Da |
| NCBI Full Name: | Regulator of G-protein signaling 19 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 19 |
| NCBI Official Symbol: | RGS19 |
| NCBI Official Synonym Symbols: | GAIP; RGSGAIP |
| NCBI Protein Information: | regulator of G-protein signaling 19 |
| UniProt Protein Name: | Regulator of G-protein signaling 19 |
| UniProt Synonym Protein Names: | G-alpha-interacting protein; GAIP |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS19 |
| UniProt Entry Name: | RGS19_HUMAN |
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