RBM38 Antibody (PACO20326)
- SKU:
- PACO20326
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | RBM38 Antibody (PACO20326) |
| Antibody SKU: | PACO20326 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human RBM38 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20326(RBM38 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20326(RBM38 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | RBM38 is a cell cycle protein found in the cytosol and the nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acid, , respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3’-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain. |
| Synonyms: | RNA binding motif protein 38 |
| UniProt Protein Function: | CDH4: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. Expressed mainly in brain but also found in other tissues.Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 20q13.3Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: heterophilic cell adhesion; axon guidance; intercellular junction assembly and maintenance; positive regulation of axon extension; cell adhesion; homophilic cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H0Z9 |
| NCBI GenInfo Identifier: | 34577107 |
| NCBI Gene ID: | 55544 |
| NCBI Accession: | NP_059965 |
| UniProt Secondary Accession: | Q9H0Z9,Q9H0Z9 |
| UniProt Related Accession: | Q9H0Z9 |
| Molecular Weight: | 26kDa |
| NCBI Full Name: | RNA-binding protein 38 isoform a |
| NCBI Synonym Full Names: | RNA binding motif protein 38 |
| NCBI Official Symbol: | RBM38 |
| NCBI Official Synonym Symbols: | RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2 |
| NCBI Protein Information: | RNA-binding protein 38 |
| UniProt Protein Name: | Cadherin-4 |
| UniProt Synonym Protein Names: | Retinal cadherin |
| Protein Family: | |
| UniProt Gene Name: | CDH4 |
| UniProt Entry Name: | CADH4_HUMAN |
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