Rat Thrombomodulin Recombinant Protein (RPES4057)
- SKU:
- RPES4057
- Product type:
- Recombinant Protein
- Host species:
- HEK293 Cells
- Reactivity:
- Rat
Frequently bought together:
Description
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Rat Thrombomodulin Recombinant Protein
Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.
| Product Name: | Rat Thrombomodulin Recombinant Protein (RPES4057) |
| Product Code: | RPES4057 |
| Size: | 10µg |
| Species: | Rat |
| Expressed Host: | HEK293 Cells |
| Synonyms: | THBD |
| Accession: | O35370 |
| Sequence: | Met1-Ser517 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method |
| Protein Construction: | A DNA sequence encoding the rat THBD (O35370) (Met1-Ser517) was expressed with a polyhistidine tag at the C-terminus. |
| Purity: | > 90 % as determined by SDS-PAGE |
| Mol Mass: | 55.2 kDa |
| AP Mol Mass: | 95 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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