Rat IL 7 Recombinant Protein (RPPB0544)
- SKU:
- RPPB0544
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Rat
- Target:
- IL 7
- Synonyms:
- Lymphopoietin 1 (LP-1)
- pre-B cell factor
- IL-7
- Source:
- Escherichia Coli
- Uniprot:
- P56478
Description
Product Name: | Rat IL 7 Recombinant Protein |
Product Code: | RPPB0544 |
Size: | 10µg |
Species: | Rat |
Target: | IL 7 |
Synonyms: | Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7. |
Source: | Escherichia Coli |
Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
Formulation: | Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4. |
Solubility: | It is recommended to reconstitute the lyophilized IL-7 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Stability: | Lyophilized IL-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-7 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
Purity: | Greater than 98.0% as determined by SDS-PAGE. |
Amino Acid Sequence: | DCHIKDKDGK AFGSVLMISI NQLDKMTGTD SDCPNNEPNF FKKHLCDDTK EAAFLNRAAR KLRQFLKMNI SEEFNDHLLR VSDGTQTLVN CTSKEEKTIK EQKKNDPCFL KRLLREIKTC WNKILKGSI |
Biological Activity: | The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is less than 0.2ng/ml, corresponding to a specific activity of >5,000,000IU/mg. |
IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.
IL 7 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 15.0kDa.The IL 7 is purified by proprietary chromatographic techniques.
UniProt Protein Function: | Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. |
NCBI Summary: | hematopoietic cytokine; involved in immune response and brain tumor growth [RGD, Feb 2006] |
UniProt Code: | P56478 |
NCBI GenInfo Identifier: | 3024010 |
NCBI Gene ID: | |
NCBI Accession: | P56478.1 |
Molecular Weight: | 15.0 kDa |
NCBI Full Name: | Interleukin-7 |
UniProt Protein Name: | Interleukin-7 |
Protein Family: | Interleukin |
UniProt Gene Name: | Il7 |
UniProt Entry Name: | IL7_RAT |