Rat IL 21 Recombinant Protein (RPPB0635)
- SKU:
- RPPB0635
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Rat
- Target:
- IL 21
- Synonyms:
- Interleukin-21
- IL-21
- Il21
- Source:
- Escherichia Coli
- Uniprot:
- A3QPB9
Description
| Product Name: | Rat IL 21 Recombinant Protein |
| Product Code: | RPPB0635 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL 21 |
| Synonyms: | Interleukin-21, IL-21, Il21. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Rat IL-21 was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Rat IL21 in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Rat IL-21 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rat IL21 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | HKSSPQRPDH LLIRLRHLMD IVEQLKIYEN DLDPELLTAP QDVKGQCEHE AFACFQKAKL KPSNTGNNKT FINDLLAQLR RRLPAKRTGN KQRHMAKCPS CDLYEKKTPK EFLERLKWLL QKMIHQHLS |
| Biological Activity: | The biological activity is measured by its ability to proliferate activated B cells. |
IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naive B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (°C) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Interleukin-21 Rat Recombinant produced in E.Coli is a single, non-glycosilated polypeptide chain containing 129 amino acids and having a total molecular mass of 15.2kDa. The Rat IL-21 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation |
| UniProt Code: | A3QPB9 |
| NCBI GenInfo Identifier: | 157817103 |
| NCBI Gene ID: | 365769 |
| NCBI Accession: | NP_001102413.1 |
| UniProt Related Accession: | A3QPB9 |
| Molecular Weight: | 17,065 Da |
| NCBI Full Name: | interleukin-21 |
| NCBI Synonym Full Names: | interleukin 21 |
| NCBI Official Symbol: | Il21 |
| NCBI Official Synonym Symbols: | IL-21 |
| NCBI Protein Information: | interleukin-21 |
| UniProt Protein Name: | Interleukin-21 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il21 |
| UniProt Entry Name: | IL21_RAT |
Related Products
