Rat Ig Kappa chain monoclonal antibody (FITC) (AGIM0568)

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SKU:
AGIM0568
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Rat
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MRC OX-12
Conjugation:
FITC
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:Rat Ig ? chain monoclonal antibody (FITC)
Product Code:AGIM0568
Size:500 µL
Reactivity:Rat
Clone:MRC OX-12
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P07204
UniProt Protein Function:thrombomodulin: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THPH12). A hemostatic disorder characterized by a tendency to thrombosis. Defects in THBD are a cause of susceptibility to hemolytic uremic syndrome atypical type 6 (AHUS6). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p11.2

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function:protein binding; transmembrane receptor activity; receptor activity; calcium ion binding

Biological Process: negative regulation of fibrinolysis; response to cAMP; negative regulation of blood coagulation; response to lipopolysaccharide; female pregnancy; signal transduction; blood coagulation; leukocyte migration; response to X-ray

Disease: Thrombophilia Due To Thrombomodulin Defect; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6

NCBI Summary:The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
UniProt Code:P07204
NCBI GenInfo Identifier:136170
NCBI Gene ID:7056
NCBI Accession:P07204.2
UniProt Secondary Accession:P07204,Q8IV29, Q9UC32,
UniProt Related Accession:P07204
Molecular Weight:60,329 Da
NCBI Full Name:Thrombomodulin
NCBI Synonym Full Names:thrombomodulin
NCBI Official Symbol:THBD  
NCBI Official Synonym Symbols:TM; THRM; AHUS6; BDCA3; CD141; THPH12  
NCBI Protein Information:thrombomodulin; fetomodulin; CD141 antigen
UniProt Protein Name:Thrombomodulin
UniProt Synonym Protein Names:Fetomodulin; CD_antigen: CD141
Protein Family:Thrombomodulin
UniProt Gene Name:THBD  
UniProt Entry Name:TRBM_HUMAN

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