Rat Growth Hormone Recombinant Protein (RPPB0335)
- SKU:
- RPPB0335
- Product type:
- Recombinant Protein
- Size:
- 200ug
- Species:
- Rat
- Target:
- Growth Hormone
- Synonyms:
- GH1
- GH
- GHN
- GH-N
- Source:
- Escherichia Coli
- Uniprot:
- P01244
Description
| Product Name: | Rat Growth Hormone Recombinant Protein |
| Product Code: | RPPB0335 |
| Size: | 200µg |
| Species: | Rat |
| Target: | Growth Hormone |
| Synonyms: | GH1, GH, GHN, GH-N, hGH-N,Pituitary GH, GH-1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1mg/ml) was lyophilized after extensive dialyses against 5mM phosphate buffer, 5mg mannitol and 1mg glycine. |
| Solubility: | It is recommended to reconstitute the lyophilized GH Rat in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GH Rat although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GH Rat should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE. |
GH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the gGH locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five GHs, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the GH locus. Mutations in or deletions of the gene lead to GH deficiency and short stature.
GH Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 190 amino acids and having a molecular mass of 21810 Dalton. GH is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
| NCBI Summary: | ligand for growth hormone receptor; plays a role in a number of signaling pathways [RGD, Feb 2006] |
| UniProt Code: | P01244 |
| NCBI GenInfo Identifier: | 134717 |
| NCBI Gene ID: | 24391 |
| NCBI Accession: | P01244.1 |
| UniProt Related Accession: | P01244 |
| Molecular Weight: | 24,656 Da |
| NCBI Full Name: | Somatotropin |
| NCBI Synonym Full Names: | growth hormone 1 |
| NCBI Official Symbol: | Gh1 |
| NCBI Official Synonym Symbols: | Gh; RNGHGP |
| NCBI Protein Information: | somatotropin |
| UniProt Protein Name: | Somatotropin |
| UniProt Synonym Protein Names: | Growth hormone |
| Protein Family: | Growth hormone |
| UniProt Gene Name: | Gh1 |
| UniProt Entry Name: | SOMA_RAT |
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