Rat GRO g/CINC-2a Recombinant Protein (RPPB1155)
- SKU:
- RPPB1155
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Rat
- Target:
- GRO g/CINC-2a
- Synonyms:
- Cytokine-induced neutrophil chemoattractant 2
- CINC2
- CINC-2
- Macrophage inflammatory protein 2-alpha
- Source:
- Escherichia Coli
- Uniprot:
- Q10746
Frequently bought together:
Description
| Product Name: | Rat GRO g/CINC-2a Recombinant Protein |
| Product Code: | RPPB1155 |
| Size: | 10µg |
| Species: | Rat |
| Target: | GRO g/CINC-2a |
| Synonyms: | Cytokine-induced neutrophil chemoattractant 2, CINC2, CINC-2, Macrophage inflammatory protein 2-alpha. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The Rat CXCL3 lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized GRO-gamma in sterile 18Mcm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSDKSS |
| Biological Activity: | Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml, corresponding to a specific activity of 10,000-100,000 units/mg. |
Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.
GRO-g Rat Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7.8kDa. The CXCL3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; SecretedCellular Component: cytosol; extracellular spaceMolecular Function: chemokine activity; CXCR chemokine receptor bindingBiological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; neutrophil chemotaxis; regulation of cell proliferation; response to lipopolysaccharide |
| UniProt Protein Details: | |
| NCBI Summary: | acts as a chemoattractant for neutrophils; involved in the inflammatory response [RGD, Feb 2006] |
| UniProt Code: | Q10746 |
| NCBI GenInfo Identifier: | 215273965 |
| NCBI Gene ID: | 171551 |
| NCBI Accession: | Q10746.2 |
| UniProt Secondary Accession: | Q10746,Q10747, Q5CZ55, Q9EP62 |
| UniProt Related Accession: | Q10746 |
| Molecular Weight: | 10,989 Da |
| NCBI Full Name: | C-X-C motif chemokine 3 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 3 |
| NCBI Official Symbol: | Cxcl3 |
| NCBI Official Synonym Symbols: | Cinc2; Cinc-2; Gm1960 |
| NCBI Protein Information: | C-X-C motif chemokine 3 |
| UniProt Protein Name: | C-X-C motif chemokine 3 |
| UniProt Synonym Protein Names: | Cytokine-induced neutrophil chemoattractant 2; CINC-2; Macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta |
| Protein Family: | C-X-C motif chemokine |
| UniProt Gene Name: | Cxcl3 |
| UniProt Entry Name: | CXCL3_RAT |
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