CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
Product Name:
Rat CLEC5A/MDL1/MDL Recombinant Protein (RPES5119)
Product Code:
RPES5119
Size:
20µg
Species:
Rat
Expressed Host:
HEK293 Cells
Synonyms:
CLEC5A
Accession:
F7GAV1
Sequence:
Val30-Lys190
Fusion tag:
N-His
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method
Protein Construction:
A DNA sequence encoding the rat CLEC5A (F7GAV1) (Val30-Lys190) was expressed with a polyhistidine tag at the N-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
20.6 kDa
AP Mol Mass:
36 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
