The Rat CD4 Domain 1 Conjugated Monoclonal Antibody (OX-38) is a specialized antibody developed for research involving CD4, a critical cell surface glycoprotein that plays a central role in the immune system. This monoclonal antibody, conjugated with a specific marker for easy detection and visualization, is designed for use in various experimental applications such as flow cytometry, immunohistochemistry, and immunofluorescence.CD4, a key component of the immune response, is primarily expressed on helper T cells and regulatory T cells, where it interacts with major histocompatibility complex (MHC) class II molecules. The binding specificity of the OX-38 monoclonal antibody allows for precise identification and quantification of CD4-expressing cells in rat samples, facilitating studies on immune function, T cell activation, and autoimmune diseases.
With its high affinity and specificity for the CD4 domain 1 epitope, this conjugated monoclonal antibody provides researchers with a reliable tool for investigating the role of CD4 in immune responses, viral infections, and autoimmune disorders. Its proven performance in laboratory settings makes it an invaluable reagent for studies aiming to deepen our understanding of immune cell biology and develop targeted therapies for immune-related conditions.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD4, also known as T4, is a 55kD glycoprotein member of the immunoglobin superfamily and is expressed on majority of thymocytes, macrophages, and a peripheral T cell subset (T helper cells). CD4 is a T cell co-receptor that interacts with the MHC class II molecule and is involved in T cell activation.