The Rat CD4 Domain 1 Monoclonal Antibody (APC) (OX-38) is a highly specific antibody designed for research involving the CD4 protein, a key marker of T-helper cells in the immune system. This monoclonal antibody, labeled with APC for fluorescence detection, is derived from the OX-38 hybridoma and is suitable for flow cytometry applications.CD4 is a crucial glycoprotein expressed on the surface of T-helper cells, playing a vital role in the immune response by recognizing antigens presented by major histocompatibility complex class II molecules. The OX-38 antibody specifically targets Domain 1 of the CD4 molecule, enabling precise detection and characterization of CD4-expressing cells in various experimental setups.
Research involving T-helper cells and their interactions with other immune cells is essential for understanding immune responses in health and disease. The Rat CD4 Domain 1 Monoclonal Antibody (APC) (OX-38) provides researchers with a powerful tool to investigate the role of CD4-expressing cells in immune regulation, infectious diseases, autoimmune disorders, and more. Its high specificity and fluorescence capabilities make it a valuable asset for immunology studies, offering deeper insights into the complex mechanisms of the immune system.
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
P05540
Gene ID:
24932
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD4, also known as T4, is a 55kD glycoprotein member of the immunoglobin superfamily and is expressed on majority of thymocytes, macrophages, and a peripheral T cell subset (T helper cells). CD4 is a T cell co-receptor that interacts with the MHC class II molecule and is involved in T cell activation.