Rat CD172a (SIRP) monoclonal antibody (FITC) (AGIM0572)

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SKU:
AGIM0572
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Rat
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MRC OX-41
Conjugation:
FITC
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:Rat CD172a (SIRP) monoclonal antibody (FITC)
Product Code:AGIM0572
Size:500 µL
Reactivity:Rat
Clone:MRC OX-41
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P78324
UniProt Protein Function:SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell surface; Motility/polarity/chemotaxis; Cell adhesion; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function:SH3 domain binding

Biological Process: blood coagulation; cell adhesion; leukocyte migration

NCBI Summary:The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P78324
NCBI GenInfo Identifier:91105764
NCBI Gene ID:140885
NCBI Accession:NP_001035111.1
UniProt Secondary Accession:P78324,O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2 Q9UIJ6, Q9Y4U9, A2A2E1, A8K411, B2R6C3,
UniProt Related Accession:P78324
Molecular Weight:54,967 Da
NCBI Full Name:tyrosine-protein phosphatase non-receptor type substrate 1
NCBI Synonym Full Names:signal-regulatory protein alpha
NCBI Official Symbol:SIRPA  
NCBI Official Synonym Symbols:BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1  
NCBI Protein Information:tyrosine-protein phosphatase non-receptor type substrate 1; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-b
UniProt Protein Name:Tyrosine-protein phosphatase non-receptor type substrate 1
UniProt Synonym Protein Names:Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84
Protein Family:Nonribosomal peptide synthetase
UniProt Gene Name:SIRPA  
UniProt Entry Name:SHPS1_HUMAN

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