The Purified Mouse TCR Gamma Delta Monoclonal Antibody (UC7-13D5) is a powerful tool for researchers studying T cell biology and immune responses. This monoclonal antibody, offered by AssayGenie, specifically targets the T cell receptor (TCR) gamma delta complex in mice, allowing for precise detection and analysis of this crucial immune receptor.The TCR gamma delta complex plays a unique role in the immune system, recognizing antigens in a different manner than conventional alpha beta TCRs. By targeting this specific receptor, researchers can gain insight into the functions and behaviors of gamma delta T cells in various experimental settings.This monoclonal antibody, UC7-13D5, has been rigorously validated for use in techniques such as flow cytometry, immunohistochemistry, and Western blotting, providing flexibility for different experimental needs. Its high specificity and sensitivity ensure reliable and accurate results, making it an essential tool for immunologists, cancer researchers, and those studying immune responses.
Furthermore, the ability to target the mouse TCR gamma delta complex opens up possibilities for investigating immune processes in mouse models of disease, offering valuable insights into the role of gamma delta T cells in health and disease. Researchers can utilize this antibody to further explore the functions and mechanisms of TCR gamma delta signaling, advancing our understanding of immune regulation and potentially uncovering new therapeutic targets.Overall, the Purified Mouse TCR Gamma Delta Monoclonal Antibody (UC7-13D5) from AssayGenie is a valuable resource for researchers seeking to delve deeper into the intricacies of T cell biology and immune system function. Its specificity, reliability, and versatility make it an indispensable tool for unlocking the mysteries of the gamma delta TCR complex and its impact on immune responses.
Product Title:
Purified Anti-Mouse TCR γ/δ Antibody [UC7-13D5]
SKU:
AGEL1556
Size:
25µg, 100µg
Clone No:
UC7-13D5
Synonyms:
TCR-γ/δ; γ/δ TCR;
Host Species:
Armenian Hamster
Reactivity:
Mouse
Application:
FCM
Isotype:
Armenian Hamster IgG
Isotype Control:
Purified Armenian Hamster IgG Isotype Control[PIP]
Form:
Liquid
Conjugation:
Unconjugated
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.