PPRC1 Antibody (PACO03686)
- SKU:
- PACO03686
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | PPRC1 Antibody |
| Antibody SKU: | PACO03686 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the C-terminal region of human PRC. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPRC1; KIAA0595; Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator; PRC |
| UniProt Protein Function: | PPRC1: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 10q24.32 Cellular Component: nucleoplasm; nucleus Molecular Function:ligand-dependent nuclear receptor transcription coactivator activity; transcription factor binding Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| UniProt Code: | Q5VV67 |
| NCBI GenInfo Identifier: | 74756889 |
| NCBI Gene ID: | 23082 |
| NCBI Accession: | Q5VV67.1 |
| UniProt Secondary Accession: | Q5VV67,Q5VV66, Q6P3U5, Q6P3W1, Q76N31, Q9BUJ3, Q9BZE5 Q9Y4E0, |
| UniProt Related Accession: | Q5VV67 |
| Molecular Weight: | 164,965 Da |
| NCBI Full Name: | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
| NCBI Synonym Full Names: | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| NCBI Official Symbol: | PPRC1 |
| NCBI Official Synonym Symbols: | PRC |
| NCBI Protein Information: | peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
| UniProt Protein Name: | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 |
| UniProt Synonym Protein Names: | PGC-1-related coactivator; PRC |
| Protein Family: | Peroxisome proliferator-activated receptor gamma coactivator-related protein |
| UniProt Gene Name: | PPRC1 |
| UniProt Entry Name: | PPRC1_HUMAN |
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