POU1F1 Antibody (PACO59852)
- SKU:
- PACO59852
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | POU1F1 Antibody (PACO59852) |
| Antibody SKU: | PACO59852 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pituitary-specific positive transcription factor 1 protein (34-130AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59852 diluted at 1:600 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes. |
| Synonyms: | Pituitary-specific positive transcription factor 1 (PIT-1) (Growth hormone factor 1) (GHF-1), POU1F1, GHF1 PIT1 |
| UniProt Protein Function: | Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202). |
| NCBI Summary: | This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28069 |
| NCBI GenInfo Identifier: | 4505955 |
| NCBI Gene ID: | 5449 |
| NCBI Accession: | NP_000297.1 |
| UniProt Secondary Accession: | P28069,O75757, Q15132, Q15133, Q9UD34, Q9UEL3, |
| UniProt Related Accession: | P28069 |
| Molecular Weight: | 35,669 Da |
| NCBI Full Name: | pituitary-specific positive transcription factor 1 isoform alpha |
| NCBI Synonym Full Names: | POU class 1 homeobox 1 |
| NCBI Official Symbol: | POU1F1 |
| NCBI Official Synonym Symbols: | PIT1; CPHD1; GHF-1; Pit-1; POU1F1a |
| NCBI Protein Information: | pituitary-specific positive transcription factor 1 |
| UniProt Protein Name: | Pituitary-specific positive transcription factor 1 |
| UniProt Synonym Protein Names: | Growth hormone factor 1; GHF-1 |
| Protein Family: | Pituitary-specific positive transcription factor |
| UniProt Gene Name: | POU1F1 |
| Antibodies |
| Anti-POU1F1 Antibody (CAB17976) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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