| UniProt Protein Function: | Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes (PubMed:22010633, PubMed:26612202). |
| NCBI Summary: | This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P28069 |
| NCBI GenInfo Identifier: | 4505955 |
| NCBI Gene ID: | 5449 |
| NCBI Accession: | NP_000297.1 |
| UniProt Secondary Accession: | P28069,O75757, Q15132, Q15133, Q9UD34, Q9UEL3, |
| UniProt Related Accession: | P28069 |
| Molecular Weight: | 35,669 Da |
| NCBI Full Name: | pituitary-specific positive transcription factor 1 isoform alpha |
| NCBI Synonym Full Names: | POU class 1 homeobox 1 |
| NCBI Official Symbol: | POU1F1 |
| NCBI Official Synonym Symbols: | PIT1; CPHD1; GHF-1; Pit-1; POU1F1a |
| NCBI Protein Information: | pituitary-specific positive transcription factor 1 |
| UniProt Protein Name: | Pituitary-specific positive transcription factor 1 |
| UniProt Synonym Protein Names: | Growth hormone factor 1; GHF-1 |
| Protein Family: | Pituitary-specific positive transcription factor |
| UniProt Gene Name: | POU1F1 |
