Porcine IL 1 beta Recombinant Protein (RPPB0463)

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SKU:
RPPB0463
Product type:
Recombinant Protein
Size:
10ug
Species:
Porcine
Target:
IL 1 beta
Synonyms:
Catabolin
Synonyms:
Lymphocyte-activating factor (LAF)
Synonyms:
Endogenous Pyrogen (EP)
Synonyms:
Leukocyte Endogenous Mediator (LEM)
Source:
Escherichia Coli
Uniprot:
P26889
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Description

Product Name:Porcine IL 1 beta Recombinant Protein
Product Code:RPPB0463
Size:10µg
Species:Porcine
Target:IL 1 beta
Synonyms:Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL1F2, IL-1 beta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The IL 1 beta was lyophilized from a 0.2µm filtered concentrated solution in PBS pH 7.4, containing 3 % trehalose.
Solubility:It is recommended to reconstitute the lyophilized IL 1 beta in sterile distilled H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IL 1 beta although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL 1 beta should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:ANVQSMECKL QDKDHKSLVL AGPHMLKALH LLTGDLKREV VFCMSFVQGD DSNNKIPVTL GIKGKNLYLS CVMKDNTPTL QLEDIDPKRY PKRDMEKRFV FYKTEIKNRV EFESALYPNW YISTSQAEQK PVFLGNSKGR QDITDFTMEV LSP
Biological Activity:The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 5.0 ng/ml, corresponding to a specific activity of > 2.0 × 105 IU/mg.

Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1B proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Recombinant IL 1 beta Porcine produced in E.coli cells is a non-glycosylated, homodimeric protein containing 153 amino acid chain and having a molecular mass of 17.6kDa. The IL 1 beta is purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
UniProt Code:P26889
NCBI GenInfo Identifier:47522926
NCBI Gene ID:397122
NCBI Accession:NP_999220.1
UniProt Related Accession:P26889
Molecular Weight:30,404 Da
NCBI Full Name:interleukin-1 beta
NCBI Official Symbol:IL1B  
NCBI Protein Information:interleukin-1 beta; IL-1 beta; prointerleukin-1 beta
UniProt Protein Name:Interleukin-1 beta
Protein Family:Interleukin
UniProt Gene Name:IL1B  
UniProt Entry Name:IL1B_PIG
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