Phospholipase A2 Recombinant Protein (RPPB5264)

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주문
SKU:
RPPB5264
Product type:
Recombinant Protein
Size:
0.5mg
Target:
Phospholipase A2
Synonyms:
Phospholipase A2
Synonyms:
Phosphatidylcholine 2-acylhydrolase
Synonyms:
Allergen Api m I
Synonyms:
Api m 1
Source:
Escherichia Coli
Uniprot:
P00630
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Description

Product Name:Phospholipase A2 Recombinant Protein
Product Code:RPPB5264
Size:0.5mg
Target:Phospholipase A2
Synonyms:Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Allergen Api m I, Api m 1.
Source:Escherichia Coli
Formulation:20mM Tris-HCl, pH 7.2, 1.5M urea and 50% glycerol.
Stability:Phospholipase A2 although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Protein is >90% pure as determined by 10% SDS-PAGE.
UniProt Code:P00630

Bee venom phospholipase A2 (PLA) is the main allergen in the bee sting allergy. Bee venom phospholipase A2 (BV-PLA2) is a hydrolytic enzyme which specifically cleaves the sn-2 acyl bond of phospholipids at the lipid/water interface. BV-PLA2 is a 14–16-kDa glycoprotein, consisting of 134 amino acids and displaying a single carbohydrate side chain at the residue Asn13. It is also held to be responsible for some systemic anaphylactic reactions in bee venom sensitized individuals. BV-PLA2 presents 3 peptide and a glycopeptide T cell epitopes, which are recognized by both allergic and non-allergic bee venom sensitized subjects. PLA is able to elicit both IgE mediated allergy and normal immunity to bee sting which usually is associated with high affinity IgG4 anti-PLA antibodies.

The E.Coli derived recombinant protein contains phospholipase P00630 bee venom protein epitopes, 26-162 amino acids. Phospholipase A2 P00630 Bee Venom is fused to a 6xHis tag at C-terminus

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