Phospho-VASP (Ser157) Antibody (PACO24300)
- SKU:
- PACO24300
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-VASP (Ser157) Antibody (PACO24300) |
Antibody SKU: | PACO24300 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:100 |
Species Reactivity: | Human, Mouse |
Immunogen: | Peptide sequence around phosphorylation site of serine 157 (R-V-S(p)-N-A) derived from Human VASP. |
Form: | Liquid |
Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from C6 cells untreated or treated with PMA using VASP(Phospho-Ser157) Antibody. | |
Immunohistochemical analysis of paraffin-embedded human tonsil carcinoma tissue using VASP(Phospho-Ser157) Antibody(left) or the same antibody preincubated with blocking peptide(right). |
Background: | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. |
UniProt Protein Function: | VASP: vasodilator-stimulated phosphoprotein. Actin- and profilin-binding microfilament-associated protein. The phosphorylation of VASP is dynamically regulated by cellular adhesion to extracellular matrix. |
UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: filopodium membrane; tight junction; focal adhesion; cytoplasm; plasma membrane; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding; SH3 domain binding; profilin binding Biological Process: axon guidance; positive regulation of actin filament polymerization; actin polymerization and/or depolymerization; neural tube closure; T cell receptor signaling pathway; protein homotetramerization |
NCBI Summary: | Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50552 |
NCBI GenInfo Identifier: | 1718079 |
NCBI Gene ID: | 7408 |
NCBI Accession: | P50552.3 |
UniProt Secondary Accession: | P50552,Q6PIZ1, Q93035, B2RBT9, |
UniProt Related Accession: | P50552 |
Molecular Weight: | 380 |
NCBI Full Name: | Vasodilator-stimulated phosphoprotein |
NCBI Synonym Full Names: | vasodilator-stimulated phosphoprotein |
NCBI Official Symbol: | VASP |
NCBI Protein Information: | vasodilator-stimulated phosphoprotein |
UniProt Protein Name: | Vasodilator-stimulated phosphoprotein |
Protein Family: | Vasodilator-stimulated phosphoprotein |
UniProt Gene Name: | VASP |
UniProt Entry Name: | VASP_HUMAN |
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