Phospho-VASP (S157) Antibody (PACO00273)
- SKU:
- PACO00273
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | Phospho-VASP (S157) Antibody |
Antibody SKU: | PACO00273 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
Species Reactivity: | Human, Mouse, Rat, Monkey |
Immunogen: | synthesized peptide derived from human VASP around the phosphorylation site of S157. |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | VASP; Vasodilator-stimulated phosphoprotein; VASP |
UniProt Protein Function: | VASP: vasodilator-stimulated phosphoprotein. Actin- and profilin-binding microfilament-associated protein. The phosphorylation of VASP is dynamically regulated by cellular adhesion to extracellular matrix. |
UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: filopodium membrane; tight junction; focal adhesion; cytoplasm; plasma membrane; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding; SH3 domain binding; profilin binding Biological Process: axon guidance; positive regulation of actin filament polymerization; actin polymerization and/or depolymerization; neural tube closure; T cell receptor signaling pathway; protein homotetramerization |
NCBI Summary: | Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] |
UniProt Code: | P50552 |
NCBI GenInfo Identifier: | 1718079 |
NCBI Gene ID: | 7408 |
NCBI Accession: | P50552.3 |
UniProt Secondary Accession: | P50552,Q6PIZ1, Q93035, B2RBT9, |
UniProt Related Accession: | P50552 |
Molecular Weight: | 380 |
NCBI Full Name: | Vasodilator-stimulated phosphoprotein |
NCBI Synonym Full Names: | vasodilator-stimulated phosphoprotein |
NCBI Official Symbol: | VASP |
NCBI Protein Information: | vasodilator-stimulated phosphoprotein |
UniProt Protein Name: | Vasodilator-stimulated phosphoprotein |
Protein Family: | Vasodilator-stimulated phosphoprotein |
UniProt Gene Name: | VASP |
UniProt Entry Name: | VASP_HUMAN |