Phospho-TYK2 (Tyr1054) Antibody (PACO23860)
- SKU:
- PACO23860
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Phospho-TYK2 (Tyr1054) Antibody (PACO23860) |
| Antibody SKU: | PACO23860 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R) derived from Human TYK2. |
| Form: | Liquid |
| Storage Buffer: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HT29 cells untreated(lane 1) or treated with Anisomycin(lane 2) using TYK2(Phospho-Tyr1054) Antibody. |
| Background: | TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. |
| Synonyms: | tyrosine kinase 2; JTK1; |
| UniProt Protein Function: | Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; JakA family Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; nucleus; cytosol Molecular Function:protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation Disease: Immunodeficiency 35 |
| NCBI Summary: | This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29597 |
| NCBI GenInfo Identifier: | 56405328 |
| NCBI Gene ID: | 7297 |
| NCBI Accession: | P29597.3 |
| UniProt Secondary Accession: | P29597,Q6QB10, Q96CH0, |
| UniProt Related Accession: | P29597 |
| Molecular Weight: | 1187 |
| NCBI Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
| NCBI Synonym Full Names: | tyrosine kinase 2 |
| NCBI Official Symbol: | TYK2 |
| NCBI Official Synonym Symbols: | JTK1; IMD35 |
| NCBI Protein Information: | non-receptor tyrosine-protein kinase TYK2 |
| UniProt Protein Name: | Non-receptor tyrosine-protein kinase TYK2 |
| Protein Family: | Non-receptor tyrosine-protein kinase |
| UniProt Gene Name: | TYK2 |
| UniProt Entry Name: | TYK2_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Mouse Non-receptor tyrosine-protein kinase TYK2 (Tyk2) ELISA Kit
Human Non-receptor tyrosine-protein kinase TYK2 (TYK2) ELISA Kit
